Endocrine Abstracts

IGF1 concentrations have been reported to increase with 25-hydroxyvitamin D (25(OH)D) values in population studies, but it is unclear whether this association expresses a cause-effect relationship. Mice genetically deficient of steroid receptor coactivator 3, a transcriptional coactivator for the nuclear vitamin D receptor, have significantly lower circulating IGF1 levels than wild-types.We measured serum fasting 25(OH)D and IGF1 by enzyme- and radioimmu...

Acromegaly and hypogonadism represent independent cardiovascular risk factors, worsening either different metabolic parameters or quality of life (QoL).In our cohort of 41 acromegalic males (20–82 years), 35 resulted affected by hypogonadotropic hypogonadism, while only six were eugonadal. Twenty-nine out 35 had low testosterone levels at diagnosis and six developed a post-surgical hypogonadism (testosterone cut-off: 350 ng/dl). Among hypogonadal su...

Recombinant human TSH (rhTSH) has recently been used as an adjuvant to the treatment of non-toxic multinodular goitre (MNG) by means of 131I. The aim of our study was to evaluate the efficacy of 0.2 mg rhTSH or placebo administered im on 2 consecutive days before a fixed therapeutic dose of 14 mCi of 131I. Thirteen elderly patients (71±7 years) with large non-toxic MNG (group 1) were treated with rhTSH plus 131I. While a control group of 8...

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are rare neoplasms with heterogeneous clinical behavior and potential long-term survival. In the last decade GEP–NET nomenclature has been twice reviewed. However, the 2000 WHO classification had poor prognostic power in well differentiated (WD) neoplasms. This led to the introduction of two new important parameters by the European Neuroendocrine Tumors Society (ENETS), grade and stage; the former became part of t...

Serum IGF-I levels were measured in 547 non-hypopituitaric, non acromegalic healthy subjects of both sexes in Italy to develop reference values in relation to age and gender. Participant subjects were stratified in three age classes (25–39, 40–59 and≥60 years) and IGF-I assay was carried out by double-antibody radio immunoassay. The Pearson’s correlation coefficient between age and IGF-I values was calculated by sex and pre-defined age ranges. IGF-I levels...